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目的探讨CHOP(环磷酰胺、长春新碱、阿霉素、泼尼松)+CCNU(环已亚硝脲)治疗多发性骨髓瘤近期疗效。方法选择我院2009年1月至2012年1月的25例多发行骨髓瘤患者做为观察对象,对25例患者进行CHOP+CCNU化疗方案,观察25例患者化疗后的近期疗效,不良反应及患者化疗后的中位生存时间。结果 25例患者化疗后的总有效率为68%,不良反应主要是轻度的胃肠道反应及骨髓抑制,中位生存时间为12.5个月。结论 CHOP+CCNU治疗多发性骨髓瘤近期疗效明显,药源充分,不良反应较少,可在临床推广。
Objective To investigate the short-term curative effect of CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) and CCNU (cyclosporin A) on multiple myeloma. Methods Twenty-five patients with multiple myeloma in our hospital from January 2009 to January 2012 were enrolled in this study. Twenty-five patients underwent CHOP + CCNU chemotherapy. The efficacy and adverse reactions of 25 patients after chemotherapy were observed Median survival time after chemotherapy. Results The total effective rate of chemotherapy in 25 patients was 68%. The adverse reaction was mainly mild gastrointestinal reaction and bone marrow suppression. The median survival time was 12.5 months. Conclusion CHOP + CCNU treatment of multiple myeloma with obvious short-term curative effect, sufficient source, fewer adverse reactions, can be clinically promoted.