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目的:探究首发缺血性脑卒中患者血清同型半胱氨酸(Hcy)和红细胞生成素(EPO)水平的变化和意义。方法:于2013年10月-2015年4月我科收治的首发缺血性脑卒中患者中随机选取98例作为观察组,另选取同期健康体检者98例作为对照组,检测患者的血小板、血浆纤维蛋白原(Fib)以及血白细胞水平,比较两组血清Hcy、EPO、血小板、Fib及血白细胞水平,使用Logistic回归分析法评价缺血性脑卒中病发的危险因素,采用Spearman法对血清Hcy与EPO间相关性进行分析。结果:观察组的Hcy(23.52±12.15)m IU/L与EPO(34.61±11.25)m IU/L水平显著高于对照组的(10.57±2.18)m IU/L、(17.54±5.83)m IU/L;观察组血小板、血浆纤维蛋白原(fibrinogen,Fib)及血白细胞水平均高于对照组;差异均有统计学意义(均P<0.05)。经Logistic回归分析法分析可知,Hcy为缺血性脑卒中病发的独立因素,经Spearman相关性分析显示,首发缺血性脑卒中患者EPO水平与Hcy呈正相关。结论:缺血性脑卒中病发与血清Hcy和EPO水平升高密切相关,且Hcy是导致缺血性脑卒中病发的高危因素。
Objective: To investigate the changes and significance of serum homocysteine (Hcy) and erythropoietin (EPO) levels in patients with first-episode ischemic stroke. Methods: From October 2013 to April 2015, 98 patients with ischemic stroke admitted to our department were randomly selected as the observation group. Another 98 healthy subjects were selected as the control group during the same period to detect the platelet, plasma Fibrinogen (Fib) and blood leukocyte levels, serum Hcy, EPO, platelet, Fib and white blood cell levels were compared between two groups. Logistic regression analysis was used to evaluate the risk factors of ischemic stroke. Spearman’s method was used to measure serum Hcy And EPO correlation analysis. Results: Hcy (23.52 ± 12.15) m IU / L and EPO (34.61 ± 11.25) m IU / L in the observation group were significantly higher than those in the control group (10.57 ± 2.18) m IU / L and (17.54 ± 5.83) m IU / L. The levels of platelet, fibrinogen (Fib) and leukocyte in the observation group were higher than those in the control group (all P <0.05). Logistic regression analysis showed that Hcy was an independent factor of ischemic stroke, and Spearman correlation analysis showed that there was a positive correlation between EPO level and Hcy in first-episode ischemic stroke. Conclusion: The incidence of ischemic stroke is closely related to the increase of serum Hcy and EPO levels, and Hcy is the risk factor of ischemic stroke.