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为了探讨抑癌基因P53、癌基因c-erbB-2与口腔颌面部鳞癌的关系,应用S-P免疫组化方法,对65例口腔颌面部鳞癌患者作上述两种基因蛋白的检测,结果发现:P53蛋白表达阳性38例,阳性率为58.5％c-erbB-2蛋白表达阳性50例,阳性率为76.9％。临床分期越高,阳性率也越高(P53:x~2=6.054,P<0.05;c-erbB-2:X~2=5.168,p<0.05);与病理分级亦有关系(P53:x~2=13.455,P<0.05,c-erbB-2:x~2=23.01,P<0.05);不吸烟者、5年生存者P53蛋白阳性率较低(不吸烟者:x~2=5.89,P<0.05;5年生存者:x~2=7.31,P<0.01)。因此P53、c-erbB-2对口腔颌面部鳞癌的发生、发展均起一定作用;P53可作为其预后评价指标之一,吸烟可能对P53突变有一定诱发作用。
In order to investigate the relationship between tumor suppressor gene P53 and oncogene c-erbB-2 and oral and maxillofacial squamous cell carcinoma, 65 cases of oral and maxillofacial squamous cell carcinoma were detected by SP immunohistochemistry. The results showed that: P53 protein positive 38 cases, the positive rate was 58.5% c-erbB-2 protein positive in 50 cases, the positive rate was 76.9%. The higher the clinical stage, the higher the positive rate (P53: x ~ 2 = 6.054, P <0.05; c-erbB-2: X ~ 2 = 5.168, p <0.05) The positive rate of P53 protein in 5-year survivors was lower than that in non-smokers (non-smoker: x ~ 2 = 5.89, P <0.05, c-erbB-2: , P <0.05; 5-year survival: x ~ 2 = 7.31, P <0.01). Therefore, P53 and c-erbB-2 play a role in the occurrence and development of oral and maxillofacial squamous cell carcinoma. P53 may be used as one of the prognostic indicators of smoking, and smoking may have a certain inducing effect on P53 mutation.