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为了快速诊断新生儿巨细胞病毒(CMV)感染,使临床能够及时确立诊断,便于治疗。于1986年10月～1988年12月作者对新生儿病区36例临床诊断先天性感染的新生儿进行CMV-IgM抗体测定,部分病例进行了尿病毒分离,结果15例(41.7%)阳性,对阳性者血清又进行风疹病毒IgM、弓形体IgM抗体检测,结果均阴性。根据CMV-IgM抗体一经检出即可认为存有CMV先天感染的理论,我们认为这一方法只需6小时便可报告结果,比尿病毒分离快而准确。通过实验表明,CMV在西安地区新生儿先天性感染中举足轻重,应加强注意。此外在降生后的新生儿阶段输血也可导致CMV感染,这一问题必须引起供血部门的重视。通过临床症状与体征的综合分析,作者对先天性CMV感染可能表现出的临床症征进行了叙述。
In order to quickly diagnose neonatal cytomegalovirus (CMV) infection, so that clinical diagnosis can be established in time for ease of treatment. From October 1986 to December 1988, CMV-IgM antibody was detected in 36 neonates diagnosed as congenital inpatients with neonatal ward. In some cases, the virus was isolated from urine and 15 cases (41.7%) were positive. Positive serum rubella virus IgM, toxoplasma IgM antibody test, the results were negative. Once CMV-IgM antibodies are detected, the theory of congenital CMV infection can be considered, and in our opinion, this method requires only 6 hours to report the results, which is faster and more accurate than the isolation of the virus. The experiment shows that CMV plays a decisive role in congenital neonatal infection in Xi’an. In addition, blood transfusions can also lead to CMV infection in the postnatal neonatal period, a problem that must be addressed by the donor community. Through a comprehensive analysis of clinical symptoms and signs, the authors described the possible clinical signs of congenital CMV infection.