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目的采用损益指数—累计积分(BDI-GS)评价体系对补中益气丸补益及治疗功效进行综合评价。方法 32只ICR小鼠随机分成空白对照组和补中益气丸低、中、高剂量组,每组8只。空白对照组以普通玉米粉喂养,补中益气丸低、中、高剂量组以普通玉米粉为原料,分别掺入0.75%、1.5%和2.25%的补中益气丸饲养。各组均自由摄食、饮水,隔日称体重1次,于第12天剖取心、肺、胸腺、脾、胰腺、肝、双肾、性腺、股骨9项脏器组织,称重、计算脏器系数及其损益指数(BDI)和累计积分(GS)等指标,并进行血液生化指标检测。结果各组小鼠的体重均呈降低趋势,但补中益气丸各剂量组小鼠体重降低趋势较空白对照组更缓慢。补中益气丸低、中、高剂量组小鼠脏器组织重量GS分别为10.23、11.15、11.57,脏器组织系数GS分别为9.24、9.43、10.06。补中益气丸高剂量组胸腺系数的BDI值和股骨重量系数BDI值与空白对照组比较明显升高(P<0.05或P<0.01)。补中益气丸高剂量组小鼠总蛋白含量较空白对照组增加,补中益气丸低剂量组血肌酐较空白对照组升高(P<0.05),各组其他生化指标与空白对照组比较差异均无统计学意义(P>0.05)。结论补中益气丸具有健脾补气及提高机体免疫力的功效,对骨质疏松有明显改善作用。
Objective To evaluate the effect of Bu Zhong Yi Qi Wan on replenishing benefit and treatment effect by using the Profit and Loss Index - Cumulative Score (BDI-GS) evaluation system. Methods 32 ICR mice were randomly divided into blank control group and Buzhongyiqi pill low, medium and high dose group, 8 rats in each group. The blank control group was fed with normal cornmeal, Buzhongyiqiwan low, middle and high dose groups were fed with ordinary corn flour, which were respectively mixed with Buzhongyiqi pills 0.75%, 1.5% and 2.25%. Each group was fed freely, drinking water, weight every other day, weighing 1, on the 12th day of heart, lung, thymus, spleen, pancreas, liver, kidney, gonad and femur 9 organs, weighing, Coefficient and its profit and loss index (BDI) and cumulative points (GS) and other indicators, and blood biochemical indicators. Results The body weight of mice in each group showed a decreasing tendency, but the body weight of mice in each dose group of Buzhongyiqi pill tended to decrease more slowly than that of the blank control group. The weight GS of organs of Buzhongyiqi pill in low, medium and high dose groups were 10.23,11.15 and 11.57 respectively, and the organization coefficient GS of organs were 9.24,9.43,10.06 respectively. The value of BDI and the value of BDI of thymus coefficient of Buzhongyiqi high dose group were significantly higher than those of blank control group (P <0.05 or P <0.01). Compared with the blank control group, the content of total protein in the Buzhongyiqi high-dose group increased compared with the blank control group, and the serum creatinine in the Buzhongyiqi low-dose group was higher than that in the blank control group (P <0.05) There was no significant difference between the two groups (P> 0.05). Conclusion Buzhongyiqi pill has the effect of invigorating the spleen and invigorating qi and improving the immunity of the body, and obviously improves the osteoporosis.