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目的:将临床常用的血压测定和外周动脉超声技术相结合,研究冠状动脉(冠脉)病变与大动脉弹性的相关性。方法:对所有入选病例行冠脉造影(CAG)检查,用Gensini法行冠脉病变评分,并根据CAG结果分为冠心病(CHD)组和正常对照组。于CAG前或后进行双侧颈动脉和心脏彩色多普勒检查,并测量血压、血糖、血脂、身高和体重。结果:CHD组与正常对照组比较,反映动脉弹性的脉压(PP)、PP指数(PI)、颈总动脉平均管壁张力(CWS)差异有统计学意义(P<0.01);反映早期动脉粥样硬化(CAS)的颈总动脉内-中膜增厚与SBP、PP、PI正相关,与CWS负相关,且与CWS及SBP的相关程度最高(标准回归系数为-0.799和0.392);反映冠脉AS程度的冠脉评分与PI、PP正相关,与CWS负相关,且与CWS和PP的相关程度最高(标准回归系数为-0.462和0.236)。结论:AS病变可致动脉弹性下降;早期AS与中央动脉弹性下降有关;冠脉硬化病变及其病变程度与颈动脉弹性密切相关。
Objective: To study the correlation between coronary artery (coronary) lesions and aortic elasticity by combining the commonly used blood pressure measurement and peripheral arterial ultrasound. Methods: Coronary angiography (CAG) was performed on all selected cases. Coronary lesions were evaluated by Gensini method and divided into coronary heart disease (CHD) group and normal control group according to CAG results. Bilateral carotid and cardiac color Doppler examinations were performed before and after CAG, and blood pressure, blood glucose, blood lipids, height and weight were measured. Results: Compared with normal control group, there were significant differences in PPR, PI and CWS between CHD group and normal control group (P <0.01) Intima - media thickness of common carotid arteries of atherosclerosis (CAS) was positively correlated with SBP, PP and PI, negatively correlated with CWS, and highest with CWS and SBP (standard regression coefficients -0.799 and 0.392). Coronary score, which reflects the degree of coronary arteries, was positively correlated with PI, PP, negatively correlated with CWS, and highest correlated with CWS and PP (standard regression coefficients -0.462 and 0.236). CONCLUSIONS: AS lesion may lead to decreased arterial elasticity. Early AS is associated with decreased central elastic artery. Coronary artery disease and its severity are closely related to carotid artery elasticity.