论文部分内容阅读
目的:探讨凌蔻导浊排毒方对动物实验性胃溃疡的作用及其机制。方法:按随机数字表把40只大鼠随机分成A(空白)组、B(模型)组、C(治疗)组、D(对照)组,每组10只,除空白组外,其余各组采用冰醋酸腐蚀法造模。造模后A、B两组给生理盐水,C组给凌蔻导浊排毒方,D组给奥美拉唑,均通过灌胃途径给药。测定胃组织SOD活性及PGE2的含量。结果:凌蔻导浊排毒方与奥美拉唑比较(P<0.05),能明显提高SOD和PGE2的含量。结论:凌蔻导浊排毒方可通过提高SOD活性以及PGE2的含量的机制保护胃黏膜,促进溃疡恢复。
Objective: To investigate the effect and its mechanism of Lingqi Guizhuo Detoxicant on experimental gastric ulcer in animals. Methods: Forty rats were randomly divided into A (blank) group, B (model) group, C (treatment) group, and D (control) group according to a random number table. Each group consisted of 10 groups except for the blank group. Using glacial acetic acid corrosion model. After modeling, A and B groups were given physiological saline, group C was administered to Lingzhu Guizhuo detoxification group, and group D was given to omeprazole, both of which were administered by intragastric administration. The activity of SOD and the content of PGE2 in stomach tissue were measured. RESULTS: Compared with omeprazole (P<0.05), Lingqi Guizhuo detoxification can significantly increase the content of SOD and PGE2. Conclusion: Lingqi Guizhuo detoxification can protect the gastric mucosa and promote ulcer recovery by increasing the SOD activity and the content of PGE2.