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目的探讨p27和Ki)67在乳腺浸润性导管癌中的表达及意义。方法采用免疫组织化学方法检测60例乳腺浸润性导管癌组织p27和Ki*67的表达,分析其与临床病理特征的关系。结果p27低表达率为45.0%,p27低表达与乳腺肿瘤大小、神经脉管浸润、淋巴结转移、组织学分级有关(P<0.05);Ki+67高表达率60%,Ki,67高表达与肿瘤神经脉管浸润、淋巴结转移、组织学分级有关(P<0.05);p27低表达与Ki-67高表达有关(P<0.05)。结论p27低表达、Ki.67高表达是乳腺浸润性导管癌高度恶性和预后不良的生物学指标,乳腺癌p27和Ki/67的表达可能具有相互调控作用。
Objective To investigate the expression and significance of p27 and Ki67 in breast invasive ductal carcinoma. Methods Immunohistochemistry was used to detect the expression of p27 and Ki * 67 in 60 cases of breast invasive ductal carcinoma and its relationship with clinicopathological features was analyzed. Results The low expression of p27 was 45.0%. The low expression of p27 was correlated with tumor size, vascular invasion, lymph node metastasis and histological grade (P <0.05). The high expression rate of Ki + 67 was 60% (P <0.05). The low expression of p27 was correlated with the high expression of Ki-67 (P <0.05). Conclusion The low expression of p27 and the high expression of Ki-67 are the biological indicators of malignant and poor prognosis of breast invasive ductal carcinoma. The expression of p27 and Ki / 67 in breast cancer may play a role of mutual regulation.