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癫癎并非完全是一种终身疾病,60%~70%患者经过一定时间抗癫癎药(AEDs)治疗后症状能得到缓解(至少5年不发作),缓解后及时合理地AEDs撤药将对患者的预后包括避免或减少药物不良反应以及改善生活质量等产生重要影响。对AEDs撤药的研究已有60年历史,然而目前仅依据临床经验撤药,缺乏循证医学依据。对达到撤药的要求、时机及具体方法亦无统一被认可的标准。本文就AEDs撤药对癫癎复发的影响,撤药时机、速度,撤药后复发的危险因素等方面的研究进行综述。
Epilepsy is not completely a life-long disease. Symptoms can be relieved in 60% to 70% of patients after antiepileptic drugs (for at least 5 years) after a certain period of time. A timely and reasonable withdrawal of AEDs will ease The patient’s prognosis includes avoiding or minimizing adverse drug reactions and improving quality of life. The study of withdrawal of AEDs has been 60 years of history, however, the current withdrawal based on clinical experience, the lack of evidence-based medicine. There is no uniform and accepted standard on the requirements, timing and specific methods of drug withdrawal. This review summarizes the impact of withdrawal of AEDs on the recurrence of epilepsy, the timing and speed of withdrawal, and the risk factors of recurrence after withdrawal.