目的　为了了解老年Ⅱ型糖尿病患者服用磺 (酰 )脲类降糖药引起严重低血糖的情况。方法　总结了近 2年来 2 0例老年Ⅱ型糖尿病患者服用磺 (酰 )脲类降糖药引起严重低血糖的病例。结果　引起低血糖昏迷的病例 5例 ,他们分别服用格列本脲 (2例 )、格列齐特 (1例 )、格列吡嗪 (1例 )和格列喹酮 (1例 )。结论　应用此类药物的老年患者要注意年龄、肾功能状态和进食情况 ,同时注意向患者宣传糖尿病相关知识 ,预防严重低血糖的发生。 Objective In order to understand the elderly patients with type 2 diabetes sulfonylurea hypoglycemic agents cause severe hypoglycemia. Methods The cases of severe hypoglycemia caused by taking sulfonylurea hypoglycemic agents in 20 elderly patients with type 2 diabetes over the past two years were summarized. Results In 5 cases of hypoglycemic coma, they took glibenclamide (2 cases), gliclazide (1 case), glipizide (1 case) and gliquidone (1 case). Conclusion Elderly patients with these drugs should pay attention to the age, renal function and eating status, while paying attention to the promotion of diabetes-related knowledge to prevent the occurrence of severe hypoglycemia.