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目的:观察萆薢止带片对脾虚湿瘀互结型宫颈高危人乳头瘤病毒(HPV)感染患者的疗效及免疫调节作用。方法:将75例脾虚湿瘀互结型宫颈高危HPV感染患者分为治疗组和对照组,治疗组41例采用萆薢止带片治疗3月,对照组34例不给予任何治疗。比较2组疗效及治疗前后血清肿瘤坏死因子(TNF)-α、干扰素(IFN)-α水平。结果:宫颈高危HPV感染患者年龄与TNF-α、IFN-α含量之间无相关关系。有效率治疗组为43.9%,对照组为20.6%,2组比较,差异有显著性意义(P<0.05)。治疗组治疗前后TNF-α含量比较,差异有显著性意义(P<0.05),治疗后TNF-α含量较治疗前升高。对照组治疗前后TNF-α含量比较,差异无显著性意义(P>0.05)。治疗组治疗前后IFN-α含量比较,差异有显著性意义(P<0.05),治疗后IFN-α含量较治疗前升高。对照组治疗前后IFN-α含量比较,差异无显著性意义(P>0.05)。结论:卑薢止带片可提高宫颈高危HPV感染的清除率及高危HPV感染患者TNF-α、IFN-α水平,改善机体免疫机能。
Objective: To observe the curative effect and immunomodulatory effect of Jueyi Zhitai Tablets on patients with high risk of cervical papillomavirus (HPV) infection. Methods: Seventy-five patients with high-risk HPV infection of spleen-asthenia-dampness and stasis type were divided into treatment group and control group. In treatment group, 41 cases were treated with 萆 薢 Zhizao tablets for 3 months, while 34 cases in control group were not given any treatment. The effects of two groups were compared before and after treatment with serum tumor necrosis factor (TNF) -α, interferon (IFN) -α levels. Results: There was no correlation between the age of patients with high risk HPV infection and the levels of TNF-α and IFN-α. The effective rate was 43.9% in the treatment group and 20.6% in the control group. There was significant difference between the two groups (P <0.05). The content of TNF-α in the treatment group before and after treatment had significant difference (P <0.05), and the content of TNF-α increased after treatment. The level of TNF-α in the control group before and after treatment showed no significant difference (P> 0.05). The content of IFN-α in the treatment group before and after treatment had significant difference (P <0.05), and the content of IFN-α increased after treatment. There was no significant difference in the levels of IFN-α in the control group before and after treatment (P> 0.05). CONCLUSION: The hivi block can improve the clearance rate of high risk HPV infection and the levels of TNF-α and IFN-α in patients with high-risk HPV infection and improve the immune function.