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动脉粥样硬化(AS)是慢性炎性及代谢性疾病,脂质沉积和炎性细胞浸润至血管内皮下是形成AS的主要原因,但是炎性细胞浸润的机制尚未阐明。许多国内外研究表明,趋化因子对单核细胞、巨噬细胞、T细胞等炎性细胞的迁移、活化在AS炎症反应中起重要作用。新近研究证实,趋化因子可促使血管平滑肌细胞增殖以及炎症因子和基质金属蛋白酶的合成,促进斑块不稳定的关键环节。本文就趋化因子及其受体在AS发生发展中的作用予以综述。
Atherosclerosis (AS) is a chronic inflammatory and metabolic disease. Lipid deposition and inflammatory cell infiltration into the endothelium are the main causes of AS formation, but the mechanism of inflammatory cell infiltration has not been elucidated. Many domestic and foreign studies show that chemokines play an important role in the migration and activation of inflammatory cells such as monocytes, macrophages and T cells in the inflammatory response of AS. Recent studies have confirmed that chemokines can promote the proliferation of vascular smooth muscle cells and the synthesis of inflammatory cytokines and matrix metalloproteinases, the key to promote plaque instability. This article reviews the role of chemokines and their receptors in the development of AS.