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功能性无脾(functional asplenia)系指脾脏不能积蓄~(99m)Tc 硫胶体,患者外周血片有 Howell-Jolly体、Pappenheimer 体以及球形、靶形、异形红细胞,已有报道可见于许多疾病,但未曾发现于系统性红斑狼疮(SLE)。作者在5年内发现70例 SLE 患者中有5例其外周血片提示脾功能减退,其中2例~(99m)Tc 硫胶体扫描示脾脏正常,在原发病治疗后血片恢复正常,其脾功能减退可能代表了由免疫复合物引起的单核吞噬细胞系统一过性负荷过度。另3例女性 SLE 患者分别
Functional asplenia refers to the inability of the spleen to accumulate ~ (99m) Tc sulfur colloids. There are Howell-Jolly, Pappenheimer and spherical, target-shaped and irregular red blood cells in the peripheral blood of patients. It has been reported in many diseases, But not found in systemic lupus erythematosus (SLE). In 5 years, the authors found that 5 out of 70 patients with SLE had peripheral blood splatters suggesting spleen dysfunction. Among them, 2 cases of ~ (99m) Tc sulfur colloid scintigraphy showed normal spleen, blood samples returned to normal after treatment of primary disease, and their spleen dysfunction May represent a transient over-expression in the mononuclear phagocyte system caused by immune complexes. Another 3 cases of female SLE patients