论文部分内容阅读
目的探讨阿托伐他汀在改善高血压合并高血脂患者血管内皮功能中的临床作用。方法 2009年10月～2010年12月在某院就诊的高血压合并高血脂患者167例,根据入选的先后顺序将所有患者分为观察组(阿托伐他汀20mg,n=84)和对照组(阿托伐他汀10mg,n=83),阿托伐他汀睡前服用,1次/d,干预患者服用6个月,比较用药前后各组人群血压、血脂、内皮功能变化情况。结果干预结束后,两组患者血压、血脂水平和内皮功能均有不同程度的改善,与干预前相比,差异均有统计学意义(P﹤0.05);且观察组改善水平显著优于对照组,与干预前相比,差异有统计学意义(P﹤0.05)。结论阿托伐他汀可显著改善高血压合并高血脂患者的血管内皮功能,并且与剂量存在一定关系。
Objective To investigate the clinical effect of atorvastatin on vascular endothelial function in hypertensive patients with hyperlipidemia. Methods From October 2009 to December 2010, 167 patients with hypertension and hyperlipidemia in a hospital were enrolled. All patients were divided into observation group (atorvastatin 20mg, n = 84) and control group (Atorvastatin 10mg, n = 83). Atorvastatin was taken before bedtime once a day for 6 months. The changes of blood pressure, blood lipid and endothelial function were compared between before and after treatment. Results After the intervention, blood pressure, blood lipid level and endothelial function in both groups were improved to some extent, which were significantly different from those before intervention (P <0.05); and the improvement in the observation group was significantly better than that in the control group , Compared with before intervention, the difference was statistically significant (P <0.05). Conclusions Atorvastatin can significantly improve the vascular endothelial function in hypertensive patients with hyperlipidemia, and it is related to the dose.