脂肪族、芳香族以及不饱和羧酸、酯、内酯和酰胺类化合物在THF中与aminoalane试剂(由DIBAH和氯化铵在THF中反应制备)回流反应生成腈类化合物。羧酸酯或内酯需20倍aminoalane试剂,羧酸和酰胺需40倍。13例收率52%~98%,其中酰胺是主要的副产物。该条件下,羰基a位为叔碳时,反应只生成酰胺。 Aliphatic, aromatic and unsaturated carboxylic acids, esters, lactones and amides are reacted in refluxing with aminoalane reagent (prepared from DIBAH and ammonium chloride in THF) to give the nitrile compound. Carboxylate or lactone required 20 times aminoalane reagent, carboxylic acid and amide required 40 times. 13 cases yield 52% to 98%, of which amide is the main by-product. Under this condition, the carbonyl a position is tertiary carbon, the reaction generates only amide.