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采用溶胶-凝胶法制备Fe3O4@m-SiO2磁性纳米颗粒,通过乙醇回流法或煅烧法去除模板剂分别获得了单介孔和双介孔磁性纳米颗粒。利用X射线衍射、Fourier变换红外光谱、Zeta电位仪、透射电子显微镜、低温氮吸附比表面测试仪和振动样品磁强计对其物相、结构和性能进行了表征。选用维生素B12为模型药物,研究了两种介孔材料的药物缓释行为。结果表明:Fe3O4@m-SiO2磁性纳米颗粒尺寸在60～80 nm之间;单介孔和双介孔磁性纳米颗粒的比饱和磁化强度和药物装载量分别达到51、55 A.m2/kg和104.5、110.3 mg/g;在药物缓释过程中,两种介孔材料的释药量均达到80%以上,其中,单介孔材料更有利于药物缓释。
Fe3O4 @ m-SiO2 magnetic nanoparticles were prepared by sol-gel method. Single and double mesoporous magnetic nanoparticles were obtained by ethanol refluxing or calcination to remove the template. Its phase, structure and properties were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, Zeta potential, transmission electron microscopy, low temperature nitrogen adsorption surface area analyzer and vibrating sample magnetometer. Vitamin B12 was chosen as a model drug to study the sustained release behavior of two mesoporous materials. The results show that the specific magnetic saturation magnetization and drug loading of Fe3O4 @ m-SiO2 magnetic nanoparticles ranged from 60 to 80 nm. The specific saturation magnetization and drug loading of single-mesoporous and mesoporous magnetic nanoparticles reached 51.55 A.m2 / kg and 104.5 and 110.3 mg / g, respectively. During the drug release process, the release of both mesoporous materials reached more than 80%, of which the mesoporous material was more conducive to drug release.