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目的探讨双歧杆菌三联活菌肠溶胶囊对慢性乙型肝炎后肝硬化患者肝功能及血清细胞因子水平的影响。方法选取慢性乙型肝炎后肝硬化患者86例,随机分为观察组和对照组。两组患者均予以低盐饮食、保肝和营养支持等常规治疗。观察组患者加用双歧杆菌三联活菌肠溶胶囊0.42 g/次,每天3次,连用8周。对照组患者除不使用双歧杆菌三联活菌肠溶胶囊其他治疗措施同对照组。观察并比较两组患者治疗前和治疗8周后肝功能和血清细胞因子白介素(IL)-1β和肿瘤坏死因子(TNF)-α水平的变化。结果治疗8周后,两组患者丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)和总胆红素(TB)水平较前均有不同程度下降(P<0.05或P<0.01),且观察组下降程度比对照组更明显(P<0.05);同时两组患者血清IL-1β和TNF-α水平较前均有不同程度下降(P<0.05或P<0.01),且观察组下降程度比对照组更明显(P<0.05)。结论双歧杆菌三联活菌肠溶胶囊辅助治疗慢性乙型肝炎后肝硬化患者能明显降低患者肝功能指标,加速肝功能的恢复,并能下调血清细胞因子的水平,抑制肝内炎症反应,加快患者病情的恢复。
Objective To investigate the effect of triple Bifidobacterium enteric-coated enteric-coated capsules on liver function and serum cytokines in patients with post-cirrhosis of chronic hepatitis B. Methods Eighty-six patients with cirrhosis after chronic hepatitis B were randomly divided into observation group and control group. Two groups of patients were given low-salt diet, liver and nutritional support conventional treatment. Patients in the observation group plus bifidobacterium triple viable enteric-coated enteric-coated capsules 0.42 g / times, 3 times a day, once every 8 weeks. In addition to the control group patients not using Bifidobacterium triple live Enteric-coated capsules other treatment with the control group. The changes of liver function and serum levels of interleukin (IL) -1β and tumor necrosis factor (TNF) -α were observed and compared between the two groups before treatment and after 8 weeks of treatment. Results After 8 weeks of treatment, the levels of ALT, AST and TB decreased in both groups (P <0.05 or P <0.01) (P <0.05). The levels of IL-1β and TNF-α in the two groups were significantly lower than those in the control group (P <0.05 or P <0.01), and the observation group Decreased more significantly than the control group (P <0.05). Conclusion Bifidobacterium triple viable enteric capsule adjuvant treatment of patients with chronic hepatitis B after liver cirrhosis can significantly reduce the patient’s liver function index, accelerate the recovery of liver function, and can down-regulate serum cytokines levels, inhibit liver inflammation, accelerate The patient’s condition recovered.