文献报道高血压病患者和动物模型中,血浆胰岛素水平升高,而降糖作用减弱。在高血压状态下,胰岛素对肾钠重吸收影响的报道目前尚不多,而这一点对确认胰岛素在高血压形成或发展中的作用至关重要。作者研究了自发性高血压大鼠(SHR)和正常血压的Wistar-Kyoto大鼠(WKY),接受胰岛素处理后,肾脏尿钠排泄的变化,并对两系大鼠进行了比较。实验中,将SHR和WKY大鼠分别分为3组。第1组为小剂量胰岛素组,先给予胰岛 Reported in the literature of hypertensive patients and animal models, plasma insulin levels increased, while hypoglycemic effect weakened. In hypertension, the impact of insulin on renal sodium reabsorption is not reported, and this is important to confirm the role of insulin in the development or progression of hypertension. The authors studied spontaneous hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY), after treatment with insulin, changes in renal urinary sodium excretion, and the two series of rats were compared. In the experiment, SHR and WKY rats were divided into 3 groups. Group 1 is a small dose of insulin group, first given islet