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硫化氢(H2S)已成为第三种内源性气体信号分子。H2S由胱硫醚-β-合酶、胱硫醚-γ-裂解酶和3-巯基丙酮酸转硫酶三种酶产生。呼吸节律产生于中枢神经系统脑干延髓的一个局限区域——前包钦格复合体,生理浓度的H2S对中枢性呼吸节律有“先抑制后兴奋”的双向调节作用,而高浓度H2S对呼吸节律产生抑制作用。H2S可能是通过KATP通道和环磷酸腺苷途径参与呼吸中枢节律性调控。
Hydrogen sulfide (H2S) has become the third endogenous gas signaling molecule. H2S is produced by cystathionine-β-synthase, cystathionine-γ-lyase and 3-mercaptopyruvate thiotransferase. Respiratory rhythms originate from a localized area in the central nervous system brainstem medulla oblongata - the former TSQ complex. Physiological concentrations of H2S play a bidirectional regulatory role in central respiratory rhythms “excitatory after suppression”, while high concentrations of H2S Respiratory rhythm have an inhibitory effect. H2S may be involved in the regulation of respiratory center rhythm through KATP channel and cyclic adenosine monophosphate pathway.