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邻苯二甲酸酯的抗雄激素作用可能影响暴露儿童的生殖发育。因此我们研究了宫内或环境暴露邻苯二甲酸酯的6岁儿童的生殖发育情况。我们招募了120位川东北地区2010年出生的儿童,并跟踪调查至2016年直至这些儿童年满6周岁。我们收集整理了每位儿童的出生结局,测定其骨龄、激素水平及邻苯二甲酸酯的代谢产物(邻苯二甲酸单酯(MEHP),邻苯二甲酸单丁酯(Mn BP))的水平,并评估了这些儿童的生殖发育情况。母亲尿液中邻苯二甲酸酯类代谢产物的水平与6岁儿童出生时的情况、生理特征及生殖激素的水平并不明显相关。而6岁儿童尿液中邻苯二甲酸酯类代谢产物MEHP与血清中黄体酮的水平显著相关,尤其是女孩尿液中MEHP的水平。所有儿童Mn BP的水平与血清FSH的水平显著相关。尿液邻苯二甲酸酯类代谢产物的水平与6岁儿童的生长及生殖器官的发育并不相关。因此,环境暴露邻苯二甲酸酯可能会影响儿童生殖激素的水平。邻苯二甲酸酯的环境健康效应还有待进一步研究。
Anti-androgenic effects of phthalates may affect the reproductive development of exposed children. Therefore, we studied the reproductive development of 6-year-old children who had intrauterine or environmental exposure to phthalates. We recruited 120 children born in 2010 in northeastern Sichuan and followed up until 2016 until the children reached 6 years of age. We collected and sorted out the birth outcomes for each child and determined their bone age, hormone levels, and metabolites of phthalates (MEHP, Mn BP) And assessed the reproductive development of these children. Maternal urine phthalate metabolites levels and 6-year-old child at birth, physiological characteristics and reproductive hormone levels are not significantly correlated. However, MEHP, a phthalate metabolite in urine of 6-year-old children, was significantly correlated with serum progesterone levels, especially in girls urine. The level of Mn BP in all children was significantly correlated with the level of serum FSH. Urine phthalate metabolites levels are not associated with 6-year-old children’s growth and reproductive organ development. Therefore, environmental exposure to phthalates may affect children’s reproductive hormones. Environmental health effects of phthalates have yet to be further studied.