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目的探讨洛铂联合多西他赛治疗复发转移性卵巢癌的临床疗效。方法选取安阳市肿瘤医院2011年1月至2012年1月收治的100例复发转移性卵巢癌患者进行研究,按照随机原则分为治疗组和对照组,每组50例。对照组给予洛铂进行治疗,治疗组在洛铂治疗的基础上联合使用多西他赛,治疗结束后对比两组的临床效果。结果治疗后治疗组总有效率为70%,对照组为40%,治疗组显著优于对照组(P<0.05);治疗组中不良反应显著轻于对照组,差异有统计学意义(P<0.05)。结论对于复发性转移性卵巢癌患者采用洛铂联合多西他塞治疗,临床效果显著,不良反应较轻,可显著提高患者的生活质量,值得临床广泛推广应用。
Objective To investigate the clinical efficacy of lobaplatin combined with docetaxel in the treatment of recurrent ovarian cancer. Methods A total of 100 patients with recurrent ovarian cancer who were treated in Anyang Tumor Hospital from January 2011 to January 2012 were selected and divided into treatment group and control group according to the randomized principle, with 50 cases in each group. The control group received lobaplatin for treatment. The treatment group was treated with docetaxel on the basis of lobaplatin treatment. The clinical effects of the two groups were compared after treatment. Results After treatment, the total effective rate was 70% in the treatment group and 40% in the control group, which was significantly better in the treatment group than in the control group (P <0.05). The adverse reactions in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion For patients with recurrent metastatic ovarian cancer, lobaplatin combined with docetaxel has significant clinical effect and mild adverse reactions, which can significantly improve the quality of life of patients and deserves wide application in clinic.