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目的 探讨分析端粒酶在乳腺组织中的表达对乳腺癌早期诊断的临床价值。方法 应用PCR -ELISA法 ,对 170例患者分别进行端粒酶活性检测。结果 端粒酶的表达与乳腺癌的临床分期、腋液巴结转移密切相关 (P <0 0 1)。特别是它在乳腺癌前病变中有表达。结论 端粒酶对乳腺癌的早期诊断具有重要价值 ,进一步探讨与其他癌基因的关系 ,可望成为特异性临床诊断指标
Objective To investigate the clinical value of telomerase expression in breast cancer for the early diagnosis of breast cancer. Methods PCR-ELISA was used to detect telomerase activity in 170 patients. Results The expression of telomerase was closely related to clinical stage and axillary lymph node metastasis of breast cancer (P <0.01). In particular, it is expressed in premalignant breast lesions. Conclusion Telomerase plays an important role in the early diagnosis of breast cancer. To further explore the relationship with other oncogenes, it is expected to become a specific clinical diagnostic indicator