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反应停(沙利度胺,酞胺哌啶酮,thalidomideThd)于1954年在西德合成,1956年开始在西德及欧洲国家作为一种非巴比妥药物广泛使用。1961年因用于妊娠呕吐而致新生儿畸形及死产被禁用。在上世纪90年代,有文献报道其具有治疗艾滋病及抗肿瘤的作用,并于1998年获得美国FDA承认而重新用于临床。现将其抗肿瘤的作用及其它的免疫调节作用作一综述。1 药物简介 反应停是谷氨酸衍生物,化学名称为N-2(2,6-二氧-3-哌啶基)-邻苯二甲酰亚胺。为一种白色结晶
Thalidomide (Thalidomide Thd) was synthesized in West Germany in 1954 and widely used as a non-barbiturate drug in West Germany and European countries from 1956 onwards. Neonatal malformations and stillbirth were disabled in 1961 for vomiting during pregnancy. In the 90s of last century, it has been reported in the literature that it has the effect of treating AIDS and anti-tumor and was re-used clinically when it was admitted by the U.S. FDA in 1998. Now its anti-tumor effect and other immunomodulatory effects are reviewed. A drug profile reaction stop is a glutamate derivative, the chemical name is N-2 (2,6-dioxo-3-piperidinyl) - phthalimide. For a white crystal