动物实验证明,前列腺素是不影响排卵,而能促使黄体溶解的药物。Hamberger 等人最近提出,PGF_(2α)在去甲肾上腺素参与下,在体内、外均能引起人的黄体溶解。已证实前列腺素合成酶抑制剂(PGSI)对灵长动物能干扰卵泡膜的破裂,但不影响黄体形成,可导致卵子闭锁。1976年 Chaudh-uri 等人曾研究,每天给人口服1.8～3.6g 阿斯匹林,不影响排卵过程,可通过类固醇激素水平证实。近来,评价一种高效价的前列腺索合成酶抑制剂,naproxen 对排卵进行研究。此外,还研究了黄体功能及分泌期子宫内膜形态学。选10名健康生育妇女,服药前有三个月的正常 Animal experiments show that prostaglandins do not affect ovulation, but can promote luteal lysis of drugs. Recently, Hamberger et al. Proposed that PGF_ (2α) can cause human luteal lysis both in vitro and in vivo with the participation of norepinephrine. Prostaglandin synthase inhibitors (PGSI) have been shown to interfere with the rupture of the follicle in primates but do not affect the formation of the corpus luteum and can cause egg occlusion. In 1976, Chaudh-uri et al. Studied that oral administration of aspirin 1.8 ~ 3.6g daily does not affect ovulation process and can be confirmed by steroid hormone levels. Recently, a high titer prostacyclin synthase inhibitor, naproxen, has been studied for ovulation. In addition, luteal function and secretory endometrial morphology were also studied. Select 10 healthy childbearing women, three months before taking the normal