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实验在氯醛糖和氨基甲酸乙酯麻醉猫上进行,用箭毒制动。以玻璃微电极记录背海马CA1区神经元放电。观察刺激中缝核(NR)对伤害性刺激内脏大神经引起的海马单位放电的影响。在记录的104个单位中,对伤害性刺激发生显著反应的82个。其中伤害性兴奋单位(NEU)38个;伤害性抑制单位(NIU)44个。伤害性无关单位(NUU)22个。刺激NR后,检测了63个单位,其中NEU的自发放电和伤害性放电出现抑制效应的,分别占单位数的40％和60％。26个NIU出现抑制加强的占60％;出现脱抑制的占25％。12个NUU,有的转变为NEU,有的转变为NIU,有的则维持原状。结果表明,海马CA1区存在内脏伤害性相关单位,该神经元分为NEU和NIU两类,刺激NR对它们中的多数均起抑制作用,并对其机制进行了讨论。
Experiments in the chloralose and urethane anesthesia cats, with arrow poison brake. The neurons of CA1 area of hippocampus were recorded by glass microelectrode. To observe the effects of stimulation of the middle raphe nucleus (NR) on noxious hippocampal unit discharge induced by visceral nociception. Of the 104 units recorded, 82 responded significantly to nociceptive stimuli. Among them, 38 were NEUs and 44 were NIH. Noxious Unit (NUU) 22. After stimulating NR, 63 units were detected, of which spontaneous NEU discharge and nociceptive discharge inhibitory effect, accounting for 40% and 60% of the number of units. Sixty-six NIUs exhibited increased suppression of 60%; de-suppression accounted for 25%. 12 NUU, some change to NEU, some change to NIU, others maintain the status quo. The results showed that visceral nociceptive units were present in the hippocampal CA1 region. The neurons were divided into two groups, NEU and NIU, which stimulated the NR to inhibit most of them and discussed the mechanism.