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目的:评价健脾补肾方联合培美曲塞和顺铂治疗晚期肺腺癌患者的临床疗效。方法:将64例晚期肺腺癌患者随机分为对照组和治疗组各32例。对照组采用培美曲塞联合顺铂方案化疗,治疗组在化疗的同时加用健脾补肾方,连用2个周期评价疗效。结果:治疗组在有效率的提高、中医临床症候的改善、生活质量改善、毒副反应减轻方面均优于对照组,具有统计学意义(P<0.05)。结论:健脾补肾方联合培美曲塞和顺铂治疗晚期肺腺癌具有增效减毒、改善症状的作用,效果显著,值得临床推广应用。
Objective: To evaluate the clinical efficacy of Jianpi Bushen Recipe in combination with pemetrexed and cisplatin in the treatment of patients with advanced lung adenocarcinoma. Methods: 64 patients with advanced lung adenocarcinoma were randomly divided into control group and treatment group, 32 cases each. The control group with pemetrexed combined with cisplatin chemotherapy, the treatment group in the chemotherapy plus Jianpi Bushen Fang, even with 2 cycles to evaluate the curative effect. Results: The treatment group was superior to the control group in improving the effective rate, improving the clinical symptoms of TCM, improving the quality of life and reducing the side effects of toxic and side effects, with statistical significance (P <0.05). Conclusion: Jianpi Bushen Recipe combined with pemetrexed and cisplatin in the treatment of advanced lung adenocarcinoma has synergistic effect of reducing toxicity and improving symptoms, and the effect is remarkable. It is worthy of clinical application.