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目的探讨大肠癌组织中肿瘤坏死因子受体（Ｔｕｍｏｒ ｎｅｃｒｏｓｉｓ ｆａｃｔｏｒ ｒｅｃｅｐｔｏｒ－ｐ５５， ＴＮＦＲ－Ｐ５５）表达的数目与临床病 理因素及肿瘤分期间的关系。方法用免疫组织化学ＳＡＢＣ法检测９１例大肠癌组织、８１例癌旁组织及１３例正常肠粘 膜标本中 ＴＮＦＲ－ｐ５５的表达。结果大肠癌组织中 ＴＮＦＲ－ｐ５５表达比癌旁组织及正常组织显著增高，癌旁组织 ＴＮＦＲ－ｐ５５ 表达亦显著高于正常组织。在大肠癌组织中，ＴＮＦＲ－ｐ５５表达与浆膜浸润程度和淋巴结转移与否呈负相关，即肿瘤侵及 浆膜或有淋巴结转移时 ＴＮＦＲ－ｐ５５表达低。同时，Ｄｕｋｅｓ Ａ期和 Ｂ期患者 ＴＮＦＲ－ｐ５５表达显著高于 Ｄｕｋｅｓ Ｃ期。结论 检测ＴＮＦＲ－ｐ５５的表达对判断大肠癌恶性程度，预测肿瘤浸润深度、淋巴结转移趋势及肿瘤分期有重要价值。
Objective To investigate the relationship between the number of tumor necrosis factor receptor (TNF-P55) expression in colorectal cancer tissues and the clinical pathological factors and tumor stage. Methods Immunohistochemistry SABC method was used to detect the expression of TNFR-p55 in 91 specimens of colorectal carcinoma, 81 specimens of paracancerous tissue, and 13 specimens of normal intestinal mucosa. Results The expression of TNFR-p55 in colorectal cancer tissues was significantly higher than that in adjacent tissues and normal tissues. The expression of TNFR-p55 in adjacent tissues was also significantly higher than that in normal tissues. In colorectal cancer, TNFR-p55 expression is negatively correlated with serosal infiltration and lymph node metastasis, that is, TNFR-p55 expression is low when the tumor invades serosa or with lymph node metastasis. At the same time, the expression of TNFR-p55 in Dukes A and B patients was significantly higher than Dukes C. Conclusion The detection of TNFR-p55 expression has important value in judging the malignant degree of colorectal cancer and predicting the depth of tumor invasion, lymph node metastasis and tumor staging.