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Objective To compare the effect of chemomechanical caries removal (CMCR) to traditional drilling (TD) on blood pressure and pulse in children. Methods Of all 105 subjects, 53 were randomly assigned to CMCR group; 52, to TD group. For each subject, the systolic pressure (SP), diastolic pressure (DP) and pulse (P) were measured at five time-point: pre-treatment, initiation of carious removal, the end of carious removal, the end of the cavity restoration, and the end of the dental care. They were recorded as T0, T1, T2, T3, and TE, respectively. The difference of SP, DP, and P within each group were analyzed. Results Of all 105 subjects, 14 were administered local anesthesia. Since local anesthesia may be a confounding factor for changes in blood pressure and pulse, only the data of the other 91 subjects that local anesthesia were not administered were analyzed. Regarding the SP, DP, and P for TD, the difference between T0 and T1 was significant (P=0.013, 0.015, 0.012 respectively), while not significant between T1 and T2, T2 and T3, T3 and TE (P>0.05). Regarding the SP, DP, and P for CMCR, the differences were not significant between every two consecutive time-points (P>0.05). The differences of the SP, DP, and P between CMCR and TD were not significant for time-points T0, T3 and TE (p>0.05), while significant for T1 and T2 (P