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溶解度数据对结晶动力学研究及结晶器优化起到重要作用,利用静态平衡法测定了缬沙坦在丁酮-异丙醚混合溶剂中278.15—323.15 K的溶解度。结果表明:缬沙坦在混合溶剂中的溶解度,随着温度和丁酮摩尔分数的变大而变大,随着异丙醚摩尔分数的变大而变小。采用Modified Apelblat、一般多项式和hybrid方程对溶解度数据进行关联,平均相对偏差分别为0.95%,0.25%,3.64%,其中一般多项式方程关联较好。用van’t Hoff分析计算了缬沙坦在溶解过程中的热力学参数(焓变、熵变和吉布斯自由能),表明溶解过程为自发吸热熵驱动过程。
Solubility data plays an important role in crystallization kinetics and mold optimization. The solubility of valsartan in 278.15-323.15 K in butanone-isopropyl ether solvent was determined by static equilibrium method. The results showed that the solubility of valsartan in mixed solvents increased with the increase of temperature and butanone mole fraction, and became smaller as the mole fraction of isopropyl ether became larger. Modified Apelblat, general polynomial and hybrid equations were used to correlate solubility data, with average relative deviations of 0.95%, 0.25% and 3.64% respectively, of which the general polynomial equations were well correlated. The thermodynamic parameters (enthalpy change, entropy change and Gibbs free energy) of valsartan during dissolution were calculated by van’t Hoff analysis, indicating that the dissolution process is the spontaneous endothermic entropy driving process.