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目的：观察他莫昔芬治疗功能性子宫出血的疗效。方法：对月经过多病人先行诊刮子宫内膜，并把内膜做病理检查确诊为功能性子宫出血病人３９例，治疗组２１例，年龄４１±ｓ１２ａ，对照组１８例，年龄３６±２２ａ。从每个周期月经ｄ５开始，治疗组给他莫昔芬１０ｍｇ，ｐｏ，ｂｉｄ×２０ｄ，对照组给己烯雌酚１ｍｇ，ｐｏ，ｑｎ，连服２０ｄ后用黄体酮２０ｍｇ，ｉｍ，ｑｄ×３ｄ。２组病人均连续用药３个周期为一个疗程，按病情轻重可用药１～２个疗程。结果：治疗组治愈率达８１％，优于对照组（２２％）。不良反应在治疗组主要为月经过少，停药后３ｍｏ恢复正常，对照组有恶心，呕吐，头昏等，持续用药能消失。结论：他莫昔芬对功能性子宫出血的治愈率较己烯雌酚为高，不良反应少。
Objective: To observe the efficacy of tamoxifen in treating functional uterine bleeding. Methods: 39 cases of functional uterine bleeding were diagnosed by endometrial pathology, 21 cases of treatment group (age 41 ± s12a, control group, 18 cases, age 36 ± 22a . From the beginning of each cycle menstruation d5, the treatment group to tamoxifen 10mg, po, bid × 20d, the control group to diethylstilbestrol 1mg, po, qn, even after 20d with progesterone 20mg, im, qd × 3d. 2 groups of patients were continuous medication 3 cycles for a course of treatment, according to the severity of the disease can be used for 1 to 2 courses. Results: The cure rate of the treatment group was 81%, better than the control group (22%). Adverse reactions in the treatment group mainly menorrhagia, returned to normal after 3 months of withdrawal, the control group had nausea, vomiting, dizziness, continuous medication can disappear. Conclusion: The cure rate of tamoxifen to dysfunctional uterine bleeding is higher than that of diethylstilbestrol, with less adverse reactions.