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检测了慢性肾功能衰(CRF)贫血患者的血清红细胞生成素(Epo)、叶酸(FA)、VitB_(12)、血清铁蛋白(SF)的浓度及外周血片的异形红细胞数结果显示:未透析 CRF 贫血患者的血清 Epo 和 FA含量比正常对照明显减少(P<0.05、0.01);VitB_(12)增高(P<0.05),少数患者的 SF 减低或可能存在溶血。说明 Epo 在 CRF 贫血机制中起重要作用。叶酸和铁的缺乏及溶血可加重贫血。
The levels of serum Epo, FA, VitB 12, SF and peripheral blood cells in patients with chronic renal failure (CRF) anemia were measured. The results showed that no Serum levels of Epo and FA in patients with dialysis CRF anemia were significantly lower than those in normal controls (P <0.05, 0.01); VitB_ (12) was increased (P <0.05), and SF in a few patients was reduced or hemolytic might exist. Epo in CRF anemia mechanism that plays an important role. Lack of folate and iron and hemolysis can aggravate anemia.