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目的 探讨干扰素α(IFNα)对肝纤维化的治疗作用。方法 雄性SD大鼠 4 0只 ,采用复合因素造成肝硬化模型 ,随机取 12只作为A组 (模型组 ) ,余大鼠分为B组 (IFNα治疗组 ) 12只 ,每日肌注IFNα 1×10 5U共 6W和C组 (对照组 ) 12只 ,每日肌注生理盐水共 6W。取肝脏组织行光镜和电镜下观察病理变化。结果 IFNα治疗组肝纤维化程度明显减轻 ,激活状态的星状细胞 (HSC)数量明显减少 ,并出现凋亡现象。结论 IFNα对肝纤维化有治疗作用。
Objective To investigate the therapeutic effect of interferon α (IFNα) on hepatic fibrosis. Methods Forty male Sprague-Dawley rats were randomly divided into two groups: group A (model group) and group B (IFNα group). Twelve daily intramuscular IFNα 1 × 10 5U total 6W and C group (control group) 12, daily intramuscular saline a total of 6W. The liver tissues were observed under light and electron microscope pathological changes. Results The degree of hepatic fibrosis in IFNα treatment group was significantly reduced, the number of activated stellate cells (HSC) was significantly reduced, and apoptosis occurred. Conclusion IFNα has a therapeutic effect on liver fibrosis.