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目的建立与临床冠心病极为相似的慢性多支冠状动脉狭窄犬动物模型。方法成年犬１９只，在左前降支（ＬＡＤ） 和左回旋支（ＬＣＸ）近端安放缩窄器，二维超声评价室壁增厚率（％ＷＴ），放射性微球定量分析心肌血流量（ＭＢＦ）。结果 术后第 ７天 ２６个（５２％）心肌节段表现为局部室壁运动异常（ＲＷＭＡ），ＬＡＤ和 ＬＣＸ供血区的平均％ＷＴ低于术前 （Ｐ＜０．０５）；但ＬＡＤ和ＬＣＸ供血区的ＭＢＦ在术后第２１天才降低（Ｐ＜０．０５）。术后第４２天有３６个（７２％）心肌节段表现为 ＲＷＭＡ，ＬＡＤ和ＬＣＸ供血区的平均％ＷＴ亦均低于术前（Ｐ＜０．０５），但仅ＬＣＸ供血区的ＭＢＦ保持低下（Ｐ＜０．０５）。结论 慢性多支冠状动脉狭窄犬模型可产生明显的节段性左室收缩功能低下，适宜于慢性可逆性心肌收缩功能障碍的研究。
Objective To establish an animal model of chronic multiple coronary stenosis in dogs closely resembling clinical coronary heart disease. Methods Nineteen adult dogs were anesthetized and placed in the proximal of left anterior descending artery (LAD) and left circumflex artery (LCX). The wall thickness (% WT) was evaluated by two-dimensional echocardiography and the myocardial blood flow MBF). Results 26 (52%) myocardial segments showed regional wall motion abnormalities (RWMA) on the 7th day after operation. The average% WT of LAD and LCX blood supply areas was lower than that before operation (P <0.05) MBF in the LCX donor zone decreased only on the 21st postoperative day (P <0.05). Thirty-six (72%) of the myocardial segments showed RWMA on day 42 postoperatively, mean% WT for LAD and LCX donations was also lower than preoperatively (P <0.05), but only for MBF maintenance in the LCX donor area Low (P <0.05). Conclusion Chronic multiple coronary artery stenosis canine model can produce significant segmental left ventricular systolic dysfunction, suitable for chronic reversible myocardial systolic dysfunction.