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目的利用磁共振扩散张量成像(DTI)技术和扩散张量纤维束示踪成像(DTT)技术观察弱视视放射的发育状况,从视放射整体功能的角度探讨屈光参差性弱视的发病机制。方法应用3.0T磁共振对8例屈光参差性弱视组、15例正常对照组进行数据采集,比较弱视组与对照组视放射、弱视组同侧视放射与对侧视放射的各向异性分数(FA)值、表观扩散系数(ADC)值,以及视放射纤维束数量和纤维体素值。结果弱视组弱视眼侧视放射与对侧视放射FA值、ADC值及纤维束数量、纤维体素值差异均没有统计学意义。两组间比较,弱视组视放射FA值、纤维体素值降低(P<0.05),弱视组视放射后半部的体素值减少差异有统计学意义(P<0.05),而视放射前半部分体素值没有明显改变。ADC值、纤维束数量两组间差异没有统计学意义。结论通过DTI及DTT技术发现屈光参差性弱视患者视放射纤维致密性、完整性与方向一致性下降,视放射纤维投射异常,存在一定程度的发育不良,但是并没有发生形态学上改变。
Objective To investigate the development of radiation in amblyopia with diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT), and to explore the pathogenesis of anisometropic amblyopia from the perspective of overall radiological function. Methods The data of 8 cases of anisometropic amblyopia group and 15 cases of normal control group were collected by 3.0T magnetic resonance imaging. The anisotropy scores of ipsilateral astigmatism and contralateral astigmatism were compared between the amblyopic group and the control group (FA) value, apparent diffusion coefficient (ADC) value, and the number of fiber bundles and fiber voxel values. Results There was no significant difference in FA value, ADC value, number of fiber bundles and fiber voids between amblyopic group and amblyopic group in amblyopic group. FA values and fibronectin values in the amblyopic group were significantly lower than those in the amblyopic group (P <0.05), while those in the amblyopic group were significantly decreased (P <0.05) Some voxel values did not change significantly. ADC value, the number of fiber bundles no significant difference between the two groups. Conclusions Dyspnea-poor amblyopia with DTI and DTT found that the optic fiber density, integrity and orientation consistency were decreased, and the optic fiber projection was abnormal. There was a certain degree of dysplasia, but no morphological changes were observed.