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目前维甲酸及其衍生物被广泛应用于急性早幼粒细胞白血病(APL)的治疗。然而越来越多的患者表现出对全反式维甲酸的耐药性。本文总结了全身因素及APL细胞本身因素在维甲酸获得性耐药中的可能作用,对维甲酸耐药问题进行探讨。
At present, retinoic acid and its derivatives are widely used in the treatment of acute promyelocytic leukemia (APL). However, more and more patients show resistance to all-trans retinoic acid. This article summarizes the systemic factors and the APL cell itself acquired resistance in retinoic acid may play a role in resistance to retinoic acid resistance issues are discussed.