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目的探讨超敏C-反应蛋白(hs-CRP)和D-二聚体(D-D)含量与冠心病患者临床类型、病变程度的关系。方法选择冠心病患者41例(急性心肌梗死10例,不稳定型心绞痛13例,稳定型心绞痛18例),同时以20例健康人作为健康对照组。分别检测血清hs-CRP、D-二聚体水平,对检测结果用统计软件进行统计学处理作对比分析。结果冠心病患者各组间血清hs-CRP、D-二聚体检测值比较差异均有统计学意义(P<0.01)。41例冠心病患者血清C-反应蛋白、D-二聚体检测值采用多元线性相关分析呈正相关,且急性心肌梗死(AMI)>不稳定型心绞痛(UAP)>稳定型心绞痛(SAP)(P<0.01)。结论血清D-二聚体的含量与冠心病的发生、发展程度有相关性,并且与病情的严重程度呈正相关,因此两者同时检测有助于早期发现诊断冠心病以及疗效的观察。
Objective To investigate the relationship between the levels of hs-CRP and D-D in patients with coronary heart disease and their clinical significance. Methods Forty-one patients with coronary heart disease (10 acute myocardial infarction, 13 unstable angina pectoris and 18 stable angina pectoris) were selected. At the same time, 20 healthy subjects were selected as healthy control group. Serum hs-CRP, D-dimer levels were detected, respectively, and the results were statistically analyzed using statistical software for comparative analysis. Results There was significant difference in serum hs-CRP and D-dimer levels among all groups (P <0.01). Serum levels of C-reactive protein and D-dimer in 41 patients with coronary heart disease were positively correlated with multivariate linear correlation analysis, and AMI> UAP> SAP> <0.01). Conclusions Serum D-dimer levels are correlated with the occurrence and development of coronary heart disease and are positively correlated with the severity of the disease. Therefore, the simultaneous detection of D-dimer and serum D-dimer contributes to the early detection and diagnosis of coronary heart disease.