肿瘤免疫耐受是一个获得性免疫应答的过程,许多机制参与调节。吲哚胺2,3-二氧化酶(IDO)是体内肝外色氨酸沿犬尿氨酸代谢的限速酶。其通过诱导“色氨酸删除”环境、色氨酸代谢产物的细胞毒性作用和调节Tregs等抑制T淋巴细胞增殖、活化,共同诱导肿瘤免疫耐受。抑制IDO可为今后肿瘤临床治疗提供新思路和方法。 Tumor immune tolerance is an adaptive immune response process, many mechanisms involved in regulation. Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme that metabolizes uropathogenic tryptophan in kynurenine in vivo. It induces tumor immune tolerance by inducing the “tryptophan” environment, the cytotoxicity of tryptophan metabolites, and the regulation of Tregs and so on to inhibit the proliferation and activation of T lymphocytes. Inhibition of IDO can provide new ideas and methods for future clinical treatment of tumors.