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鉴于缺血心肌中各种溶血磷酸甘油酯或cAMP的聚积与心脏电生理机能恶化密切相关。因此作者认为溶血卵磷脂可能是通过刺激腺苷酸环化酶而使缺血区心肌内cAMP增高。据此,作者检查了溶血卵磷脂(以下简称LPC)的聚积对破碎细胞标本中腺苷酸环化酶和磷酸二脂酶活性的影响以及对离体灌流兔心中cAMP含量的影响等项研究。LPC(0.4～1.2mmol/L)可使破碎细胞标本中腺苷酸环化酶的活性大约增强30％,而对磷酸二脂酶的活性没有影响。LPC(1和2 mmol/L)不改变异丙基肾上腺素激活的腺苷酸环化酶之活性,可是LPC(1 mmol/L)却可使氟化物激活
In view of the ischemic myocardium in a variety of lysophosphatidic acid or cAMP accumulation and cardiac electrophysiological function is closely related. Therefore, the authors believe that lysophosphatidylcholine may increase cAMP in ischemic myocardium by stimulating adenylate cyclase. Accordingly, the authors examined the effects of lysolecithin (hereinafter referred to as LPC) accumulation on adenylate cyclase and phosphodiesterase activity in fragmented cell samples and their effect on cAMP content in isolated perfused rabbit hearts. LPC (0.4 ~ 1.2mmol / L) can increase the activity of adenylate cyclase in the broken cell samples by about 30%, but has no effect on the activity of phosphodiesterase. LPC (1 and 2 mmol / L) did not alter the activity of isoproterenol-activated adenylate cyclase, but LPC (1 mmol / L) activated fluoride