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目的探讨艾滋病病毒(HIV)感染者和艾滋病(AIDS)患者合并宫颈癌与癌前病变的相关影响因素。方法以在本院诊治的40例HIV/AIDS(HIV抗体阳性)合并宫颈癌与癌前病变患者为观察组,等距抽样选择同期在本院诊治的40例HIV抗体阴性宫颈癌与癌前病变患者为对照组,对其相关危险行为、宫颈癌与癌前病变的程度进行横断面调查。结果观察组中HIV感染者19例(47.50%),AIDS患者21例(52.50%);两组多性伴、性病史、配偶/固定性伴有多性伴、配偶/固定性伴HIV抗体阳性差异具有高度统计学意义(45.00%比10.00%、37.50%比7.50%、82.50%比27.50%、72.50%比2.50%,P均<0.01);两组宫颈病变不同程度中CINⅢ与宫颈癌的发生率差异具有高度统计学意义(57.50%比15.00%与27.50%比2.5%,P均<0.01),CINⅡ的发生率与孕次≥3次比较差异无统计学意义(15.00%比32.50%,65.00%比50.00%)。结论 HIV/AIDS患者合并宫颈癌与癌前病变的影响因素与多性伴、性病史、配偶/固定性伴有多性伴、配偶/固定性伴HIV抗体阳性密切相关;HIV抗体阳性者CINⅢ与宫颈癌的发生率显著高于HIV抗体阴性者。
Objective To investigate the relationship between cervical cancer and precancerous lesions in patients with HIV and AIDS. Methods 40 cases of HIV / AIDS-positive cervical cancer and precancerous lesions treated in our hospital were selected as the observation group. 40 cases of HIV-negative cervical cancer and precancerous lesions Patients as control group, the relevant risk behavior, cervical cancer and precancerous lesions were cross-sectional survey. Results In the observation group, there were 19 cases (47.50%) of HIV-infected patients and 21 cases (52.50%) of AIDS patients. There were two groups of polygamous, history of sexually transmitted diseases, multiple sexual partners with spouses / fixed sex and HIV / (45.00% vs 10.00%, 37.50% vs 7.50%, 82.50% vs 27.50%, 72.50% vs 2.50%, P <0.01 respectively). The incidences of CINⅢ and cervical cancer were significantly different between the two groups (57.50% vs 15.00% vs 27.50% vs 2.5%, P <0.01 respectively). There was no significant difference in the incidence of CINⅡ between the third and third trimester pregnancies (15.00% vs. 32.50%, 65.00 % Than 50.00%). Conclusion The influencing factors of cervical cancer and precancerous lesions in HIV / AIDS patients are closely related to multiple sexual partners, history of sexually transmitted diseases, multiple sexual partners with spouses / fixed sex and positive HIV / The incidence of cervical cancer was significantly higher than that of HIV-negative people.