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目的探讨肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征的疗效和临床价值。方法对27例确诊为新生儿呼吸窘迫综合征(NRDS)的患儿随机分为观察组及对照组,观察组13例除给予吸氧、吸痰、控制感染、保暖、预防出血、有机械通气指征给予人工辅助通气等常规治疗措施外,另给予外源性肺表面活性物质固尔苏(PS)按100 mg/kg气管内给药,对照组14例只给予常规治疗措施,观察治疗后两组患儿临床氧合指标表现,血气分析和呼吸机参数变化,病情转归。结果用药后观察组患儿呼吸窘迫及皮肤紫绀症状,血气分析等临床氧和指标均明显改善,呼吸机参数较用药前下降,呼吸机使用时间缩短,差异有统计学意义(P<0.05),13例均存活,无死亡病例,对照组临床氧合指标有不同程度改变,存活11例,死亡3例,差异有统计学意义(P<0.05)。结论 PS能快速、安全、有效地改善NRDS患儿的临床症状及肺功能,降低呼吸机使用参数及使用时间,降低死亡率。
Objective To investigate the efficacy and clinical value of pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome. Methods Twenty-seven cases of neonatal respiratory distress syndrome (NRDS) were randomly divided into observation group and control group. In the observation group, 13 cases were treated with oxygen inhalation and suctioning, infection control, warm-keeping, bleeding prevention and mechanical ventilation Indications for artificial supplementary ventilation and other conventional treatment measures, the other given exogenous pulmonary surfactant Guer sulfur (PS) by tracheal intratracheal administration of 100 mg / kg, the control group of 14 patients were given only conventional treatment measures, after treatment Clinical oxygenation performance of two groups of children, blood gas analysis and changes in ventilator parameters, the prognosis. Results After treatment, respiratory oxygen and skin cyanosis were observed in children in observation group. Clinical oxygen index and blood gas analysis were significantly improved. Ventilator parameters decreased compared with those before treatment and ventilation machine time was shortened (P <0.05) Thirteen patients survived without any death. The clinical oxygenation index of the control group changed in varying degrees, with 11 cases survived and 3 died. The difference was statistically significant (P <0.05). Conclusion PS can rapidly, safely and effectively improve the clinical symptoms and pulmonary function of NRDS children, reduce the use of ventilator parameters and the use of time, reduce mortality.