本科于1996年1月～1996年12月应用酮康唑治疗新生儿鹅口疮42例,疗效满意,现报告如下。 1 临床资料 1.1 一般资料:本组42例,男20例,女z2例。日龄3～7天12例,～14天26例,～28天4例。原发病包括新生儿脐炎12例,肺炎8例,硬肿症10例,败血症3例,新生儿窒息8例,肠炎6例。其中早产儿32例,足月儿10例。鹅口疮的诊断符合《实用新生儿学》标准。 1.2 治疗方法:在治疗原发病的同时,加用酮康唑。酮康唑200mg研成粉末与20mL生理盐水混匀后局部涂布口腔,每天3～5次。 1.3 疗效评价:显效:用药24～48小时后,口腔粘膜上白色膜状物全部消失,症状消失,涂片镜检霉菌孢子体和菌丝(一)。有效:用药72小时后,白色膜状物大部分消失,症状减轻,但涂片镜检仍可见孢子体和菌丝。无效:用药96小时后,白色膜状物未见减少。 2 结果 Undergraduate in January 1996 ~ December 1996 application of ketoconazole in the treatment of 42 cases of neonatal thrush with satisfactory results, are as follows. 1 clinical data 1.1 General Information: The group of 42 patients, 20 males and 27 females. Day 3 to 7 days in 12 cases, ~ 14 days in 26 cases, ~ 28 days in 4 cases. The primary disease included 12 cases of neonatal omphalitis, 8 cases of pneumonia, 10 cases of sclerema, 3 cases of sepsis, 8 cases of neonatal asphyxia and 6 cases of enteritis. 32 cases of preterm children, 10 cases of full-term children. Thrush diagnosis in line with “Practical Neonatology” standard. 1.2 Treatment: In the treatment of primary disease at the same time, add ketoconazole. Ketoconazole 200mg into powder and 20mL saline mixed local oral coating, 3 to 5 times a day. 1.3 Efficacy Evaluation: Markedly effective: 24 to 48 hours after treatment, the oral mucosa on the white film all disappear, the symptoms disappear, smear microscopic fungal spores and mycelium (a). Effective: 72 hours after treatment, the majority of white film disappeared, reduce the symptoms, but smear microscopy still visible spores and mycelium. Invalid: 96 hours after treatment, no reduction of white film. 2 results