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58例HBsAg 无症状携带者第7～12年的动态变化研究结果表明,48.28%仍为持续稳定的无症状携带者,仅10%其HBsAg 阴转或康复;24人在携带过程中出现肝功能异常,发生急性肝炎,其中14人预后良好,成为病后携带者;10人发生急性肝炎后,发展为迁肝、慢活肝。平均每年有5.91%的携带者发展成各型临床肝炎。凡有过HBsAg 阳性、慢迁肝病人或抗-HBcIgM 滴度≥1:100者,Dane 颗粒检出率均高(63.64%,70.00%,44.00%),三者检出率在统计学上无显著性差异(P>0.05),均有较强的传染性;因此在乙型肝炎防治工作中应列为重点对象。
58 cases of HBsAg asymptomatic carriers of 7 to 12 years of dynamic changes in the study results showed that 48.28% remained asymptomatic carriers of sustained and stable, only 10% of its HBsAg negative or rehabilitation; 24 were in the process of carrying liver function Abnormalities, the occurrence of acute hepatitis, 14 patients with a good prognosis, become a carrier after the illness; 10 after the occurrence of acute hepatitis, the development of moving liver, slow living liver. An average of 5.91% of carriers each year develop into various types of clinical hepatitis. The detection rate of Dane particles were high (63.64%, 70.00%, 44.00%) in any HBsAg-positive, slow-moving liver patients or anti-HBcIgM titer≥1: 100, Significant differences (P> 0.05), are highly contagious; Therefore, prevention and treatment of hepatitis B should be listed as a key target.