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白塞氏综合征为一全身性疾病,其肠道病变主要为溃疡性结肠炎或回结肠炎。发生率各国相差悬殊,自0～40%不等,男女无差别。肠道病变的症状为腹痛、腹泻(一般为血性)、高热、严重消瘦,常有穿孔、出血、脓疡、瘘管等并发症。回肠或回盲部溃疡穿孔所致的腹膜炎常为此综合征的首发表现;此外并常可有非特异性炎症和低色素小红细胞缺铁性贫血。肠道病变可见于白塞氏综合征的4种组织相容性抗原患者(即HLAB_5、B_(27)、B_(12)和A_2),而以HLAB_(12)者多见。循环免疫复合物升高见于60%的病例.
Behcet’s syndrome is a systemic disease with predominantly intestinal ulceration or ulcerative colitis. The incidence of disparity between countries, ranging from 0 to 40%, no difference between men and women. Symptoms of intestinal lesions of abdominal pain, diarrhea (usually bloody), fever, severe weight loss, often perforation, bleeding, abscess, fistula and other complications. Peritonitis caused by perforation of the ileum or ileocecal ulcer is often the first manifestation of this syndrome; in addition, and often can have non-specific inflammation and hypochromic red cell anemia. Intestinal lesions were found in four histocompatibility antigens (HLAB_5, B_ (27), B_ (12) and A_2) of Behçet’s syndrome, but more common in patients with HLAB_ (12). Increased circulating immune complexes found in 60% of cases.