论文部分内容阅读
研制布洛伪麻混悬液，以方便小儿、老人及吞咽困难的患者使用，同时达到快速起效的目的。方法：以布洛芬、盐酸伪麻为主药，以黄原胶、预胶化淀粉、吐温-80等为稳定剂制各布洛伪麻混悬液，对其含量测定方法、粒径大小及分布、沉降容积比，对热、湿、光等的稳定性作了考察，并对其临床疗效作了初步观察。结果：本制剂制备工艺简单，含量测定用HPLC内标法，简便易行，回收率高；平均粒径小于4μp，且分布均匀；加速高心沉降后沉降容积比为0．91，稳定性良好；比布洛伪麻片起效快（P＜0.01）。结论：本制剂丰富了临床制剂品种，使用方便，起效迅速，可作为医院新制剂开发。
The development of brucellosis suspension, to facilitate the use of pediatric, elderly and dysphagia patients, while achieving the purpose of rapid onset. Methods: ibuprofen and pseudoephedrine hydrochloride as the main drug, xanthan gum, pregelatinized starch, Tween -80 and other stabilizers for the preparation of the suspension of budesonide pseudoephedrine, the determination of its content, particle size Size and distribution, sedimentation volume ratio, the stability of the heat, humidity, light and so on were investigated, and its clinical efficacy was initially observed. Results: The preparation method of the preparation was simple and the content was determined by HPLC with internal standard method, which was simple and easy to operate with high recovery rate. The average particle size was less than 4μp and the distribution was uniform. The sedimentation volume ratio after accelerating high center settlement was 0.91 and the stability was good ; Bibuogu pseudoephedrine onset faster (P <0.01). Conclusion: The preparation enriches the variety of clinical preparations, is easy to use and has rapid onset and can be developed as a new formulation of the hospital.