目的探讨5-氨基酮戊酸光动力(ALA-PDT)联合CO2激光治疗面部表浅型基底细胞癌的疗效。方法选取面部表浅型基底细胞癌患者48例,随机分为观察组及治疗组,每组24例。两组患者均采用ALA-PDT治疗,每周1次,共3次。观察组在第1次治疗前先用CO2激光清除表面瘤体后,再采用ALA-PDT治疗。术后每2个月复诊观察1次,12个月后取皮损组织病理检查,观察效果。结果治疗后,观察组总有效率高于对照组(100%vs.70.8%)(χ2=12.63,P<0.05)。治疗期间两组均无严重不良反应事件发生。结论 ALA-PDT联合CO2激光治疗面部表浅型基底细胞癌安全有效。 Objective To investigate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with CO2 laser in the treatment of superficial basal cell carcinoma of the face. Methods Forty-eight patients with superficial basal cell carcinoma of the face were randomly divided into observation group and treatment group, with 24 cases in each group. Both groups were treated with ALA-PDT once a week for 3 times. The observation group before the first treatment with CO2 laser to clear the surface of the tumor, then the use of ALA-PDT treatment. Follow-up was observed every 2 months after operation, and pathological examination was performed 12 months later to observe the effect. Results After treatment, the total effective rate in observation group was higher than that in control group (χ2 = 12.63, P <0.05). During the treatment, no serious adverse events occurred in both groups. Conclusion ALA-PDT combined with CO2 laser treatment of superficial basal cell carcinoma of the face is safe and effective.