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目的:探究早期规范化液体复苏治疗严重脓毒(SIRS)症、脓毒性休克的影响因素及临床效果。方法:将68例严重SIRS、脓毒性休克患者分为生存组和死亡组,比较两组治疗前后N末端-B型钠尿肽水平、c Tn I水平、血乳酸及动脉血氧分压,评价患者治疗依从性对复苏结局的影响。结果:本组68例患者,经早期规范化液体复苏治疗,存活率为66.2%,其中存活患者24 h治疗达标率(86.7%)及依从性(86.7%)均高于死亡患者(39.1%、65.2%),比较差异显著(P<0.05);与死亡组相比,存活组患者治疗后心脏功能及血气指标改善更为明显(P<0.05)。结论:早期规范化液体复苏治疗严重SIRS、脓毒性休克,有助于改善患者心脏功能及血气状况,降低病死率。
Objective: To explore the influencing factors and clinical effects of early standardized fluid resuscitation on severe sepsis (SIRS) and septic shock. Methods: Sixty-eight patients with severe SIRS and septic shock were divided into survival group and death group. The levels of N-terminal B-type natriuretic peptide, cTn I, blood lactic acid and arterial oxygen tension were compared between the two groups before and after treatment Impact of Patient Treatment Compliance on Recovery Outcomes. Results: The survival rate was 66.2% in 68 patients treated with early standardized fluid resuscitation. The survival rate (86.7%) and compliance (86.7%) of surviving patients at 24 h were higher than that of patients with death (39.1%, 65.2 %), The difference was significant (P <0.05). Compared with the death group, the survivors’ cardiac function and blood gas index improved more obviously (P <0.05). Conclusion: Early standardization of liquid resuscitation treatment of severe SIRS, septic shock, help to improve the patient’s cardiac function and blood gas conditions, reduce mortality.