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目的观察阿托伐他汀钙对动脉粥样硬化的治疗作用。方法选择60例缺血性脑血管病伴颈动脉粥样硬化患者,采用病例对照的方法将患者随机分为实验组与对照组,每组30例,均给予常规和综合性治疗。实验组同时给予阿托伐他汀钙片,20 mg/d,治疗12个月,观察两组患者颈动脉斑块的内膜中层厚度(IMT)和斑块面积变化情况。结果实验组治疗前后颈动脉IMT(P<0.05)、斑块面积显著降低(P<0.01);对照组治疗前后颈动脉IMT、斑块面积比较差异无统计学意义。结论阿托伐他汀钙可以显著促进动脉斑块的消退,降低动脉厚度,疗效优于常规治疗方法。
Objective To observe the therapeutic effect of atorvastatin on atherosclerosis. Methods Sixty patients with ischemic cerebrovascular disease accompanied by carotid atherosclerosis were selected. Patients were randomly divided into experimental group and control group with 30 cases in each group. All cases were given routine and comprehensive treatment. In the experimental group, atorvastatin calcium tablets (20 mg / d) were given for 12 months. The intima-media thickness (IMT) and plaque area of the carotid plaques in the two groups were observed. Results Before and after treatment, IMT (P <0.05) and area of plaque in experimental group were significantly decreased (P <0.01). There was no significant difference in carotid IMT and plaque area before and after treatment in experimental group. Conclusion Atorvastatin calcium can significantly promote arterial plaque regression and reduce arterial thickness, the effect is superior to the conventional treatment.