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登革病毒具有抗体依赖性病毒增强作用，故目前尚无有效的疫苗供临床使用。本实验用革登病毒免疫鸡、从高敏蛋黄中提取抗登革病毒因子，通过登革病毒乳鼠动物模型，观察该因子对动物的免疫保护作用。结果表明：用致死量的登革病毒攻击乳鼠，实验组的病死率为32％，因子对照组的病死率为100％，两组差异非常显著（P＜0．01）。实验组病死扣鼠平均存活时间为9．17±2．04天，因子对照组为7．82±0．87天，两组差异显著（P＜0．05），显示出良好的紧急预防与治疗作用。该因子可能含有一些介导细胞免疫的小分子物质，而不含有介导体液免疫的抗体，故既能避免抗体依赖性病毒增强作用，又能通过细胞免疫杀灭和清除病毒，从而具有较好的紧急预防和治疗作用，可能为登革热的防治提供一条可行的途径。
Dengue virus with antibody-dependent virus enhancement, it is currently no effective vaccine for clinical use. In this experiment, Gentamycin was used to immunize chickens to extract anti-dengue virus factor from hypersensitive yolk. The animal model of dengue virus was used to observe the protective effect of the factor on animal. The results showed that the lethal dose of dengue virus attacked the suckling mice. The mortality of the experimental group was 32% and the mortality of the factor control group was 100%. There was significant difference between the two groups (P <0.01). In the experimental group, the average survival time of the dead rats was 9.17 ± 2.04 days and that of the control group was 7.82 ± 0.87 days, showing significant difference (P <0.05), showing good emergency prevention and Therapeutic effect. This factor may contain some small molecules that mediate cellular immunity, but not antibodies that mediate humoral immunity, so it is better to both avoid antibody-dependent virus enhancement and kill and eliminate the virus by cellular immunity The role of emergency prevention and treatment may provide a feasible way for the prevention and treatment of dengue fever.