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目的研究本地区急性肝炎病原学的构成,为临床决策与预后判断提供依据。方法采用试剂盒检测入选患者血清各型肝炎病毒的标记物,运用化学发光法检测与肝脏有关的自身免疫性抗体及其他相关指标,结合临床资料,对检测的结果进行分析。结果153例患者中病毒性肝炎56例(36.60%),药物性肝炎47例(30.72%),胆源性肝损21例(13.72%),自身免疫性肝病12例(7.84%);非酒精性脂肪肝10例(6.54%);肿瘤5例(3.27%);酒精性肝炎2例(1.31%);药物性肝炎中老年组19例(44.19%),非老年组为28例(25.45%),病毒性肝炎中老年组9例(20.93%),非老年组为47例(42.73%)。结论非老年组以病毒性肝炎为主,老年组以药物性肝炎为主,其中又以中药引起的肝功能异常为常见,其他原因引起的急性肝炎较为少见。
Objective To study the composition of acute hepatitis etiology in the region and provide evidence for clinical decision-making and prognosis. Methods The kit was used to detect the markers of hepatitis B virus in selected patients. The chemiluminescence method was used to detect the autoantibodies and other related indicators related to the liver. Combined with the clinical data, the results were analyzed. Results Among the 153 patients, 56 (36.60%) were viral hepatitis, 47 (30.72%) were drug-induced hepatitis, 21 (13.72%) were biliary-type liver damage and 12 (7.84%) were autoimmune liver disease 10 cases of fatty liver (6.54%), 5 cases of tumor (3.27%), 2 cases of alcoholic hepatitis (1.31%), 19 cases of middle-aged and elderly patients (44.19%) and 28 cases (25.45% ), 9 cases (20.93%) of middle-aged patients with viral hepatitis and 47 cases (42.73%) of non-elderly patients. Conclusions The non-elderly group mainly consists of viral hepatitis, while the elderly group mainly consists of drug-induced hepatitis. Among them, liver dysfunction caused by traditional Chinese medicine is common, while acute hepatitis caused by other causes is rare.