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目前公认利福平(RFP)与异烟肼(INH)为结核杆菌的有效杀菌剂。国内研究又确认为1/3剂量的利福定(RFD)可收到与足量RFP相似的或稍强的治疗效果,且副作用小。因而当前的结核病治疗以利福霉素与异烟肼并用其他抗痨药物已形成一种必然的趋势。尤其在短化治疗方案中RFP与INH已成为两种不可缺少的主要药物。
It is currently recognized that rifampicin (RFP) and isoniazid (INH) are effective fungicides for mycobacterium tuberculosis. Domestic studies have confirmed that one-third of the dose of rifidipine (RFD) can receive a similar or slightly stronger therapeutic effect than adequate RFP, with fewer side effects. Therefore, the current treatment of tuberculosis with rifamycin and isoniazid and other anti-tuberculosis drugs has become an inevitable trend. In particular, short-term treatment of RFP and INH programs have become indispensable two main drugs.